Description

The gene encoding androgen receptor (AR), alternatively known as the dihydrotestosterone receptor, is located on the X chromosome. It is mutant in the androgen insensitivity syndrome and in Kennedy spinal and bulbar muscular atrophy. The AR protein belongs to the class of nuclear receptors called activated class I steroid receptors, which also includes glucocorticoid receptor, progesterone receptor, and mineralocorticoid receptor. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes.

External Information

Click here for more information about the AR whole gene NGS genetic test.