Description

The BRCA1 gene encodes the E3 ubiquitin-protein ligase, and plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. BRCA1 forms several distinct complexes through association with different adaptor proteins, and each complex forms in a mutually exclusive manner (Wang et al., 2009). Mutations in the BRCA1 gene increase the risk of several types of cancer, including ovarian cancer, prostate cancer, pancreatic cancer and colon cancer.

External Information

Click here for more information about the BRCA1 whole gene NGS genetic test.