Description

The L1 cell adhesion molecule is one of a subgroup of structurally related integral membrane glycoproteins belonging to a large class of immunoglobulin superfamily cell adhesion molecules (CAMs) that mediate cell-to-cell adhesion at the cell surface. L1CAM is found primarily in the nervous system of several species and may be more aptly called a neural recognition molecule (Kenwrick et al., 2000). Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus) (Yamasaki et al., ‎1997).

External Information

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