Description

Menin is a protein encoded by the MEN1 gene, is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome) (Thakker et al., 2010). Probably, this gene is involved in the regulation of varies cell functions, as DNA replication, repair and transcription. MEN-1 syndrome is an autosomal dominant disorder characterized by varying combinations of tumors, principally nonmetastasizing tumor, but many can create striking clinical effects because of the secretion of endocrine substances (Chandrasekharappa et al., 1997).