Description

The BRCA2 is a human tumor suppressor gene, and plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability (Yoshida et al., 2004). BRCA2 and BRCA1 are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA or destroy cells if DNA cannot be repaired. Mutations in the BRCA2 gene increase the risk of several types of cancer, including ovarian cancer, prostate cancer, pancreatic cancer, melanoma, and are associated to Falconi anemia.

External Information

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