Description

The mutation analysis of BRCA1 and BRCA2 genes is carried out in order to evaluate the patient’s genetic predisposition to the development of breast and ovarian tumors. The BRCA1 and BRCA2 genes represent the main genes responsible for most cases of breast and ovarian hereditary predisposition. Some cases of breast and ovarian tumors are so-called sporadic, mutations are acquired randomly throughout life and are not inherited by the offspring. A large proportion of cancers can be hereditary. It is estimated that about 14% of breast tumors and 10% of ovarian tumors are caused by recurrent mutations in the BRCA1 and BRCA2 gene.